Study on the Synthesis of Phenylacetic Acid by Carbonylation of Benzyl Chloride under Normal Pressure

摘要/Abstract

摘要： The influences of some factors on the yield of phenylacetic acid in the carbonylation of benzyl chloride were studied in this paper. These factors included the variety and content of catalyst, and that of solvent, way of material feeding, reaction temperature, sodium hydrate concentration, triphenylphosphine content, presence of surfactant, the ratio of organic phase volume to aqueous phase volume etc. The optimum reaction conditions were found to be: with a one-time pour of 0.15 g Pd(PPh3)2Cl2, 0.24 g PPh3, 75 ml NaOH of 3.5 mol/L, 20 ml benzyl chloride and 55 ml n-butyl alcohol, and the reaction was carried out at 50 for about 3 hours. The as-obtained yield of phenylacetic acid was as high as 97.6%. In addition, the influences of the presence of phenylacetic acid and air in the reaction system were also studied. The results showed that the presence of air in the system and the entrainment of phenylacetic acid in the circulating organic phase had great influence on the reaction rate, the stability and performance of catalyst and the yield of phenylacetic acid.

关键词: synthesis, phenylacetic acid, carbonylation, phenyl chloride, dichloro-bistriphenylphosphine

Abstract: The influences of some factors on the yield of phenylacetic acid in the carbonylation of benzyl chloride were studied in this paper. These factors included the variety and content of catalyst, and that of solvent, way of material feeding, reaction temperature, sodium hydrate concentration, triphenylphosphine content, presence of surfactant, the ratio of organic phase volume to aqueous phase volume etc. The optimum reaction conditions were found to be: with a one-time pour of 0.15 g Pd(PPh3)2Cl2, 0.24 g PPh3, 75 ml NaOH of 3.5 mol/L, 20 ml benzyl chloride and 55 ml n-butyl alcohol, and the reaction was carried out at 50 for about 3 hours. The as-obtained yield of phenylacetic acid was as high as 97.6%. In addition, the influences of the presence of phenylacetic acid and air in the reaction system were also studied. The results showed that the presence of air in the system and the entrainment of phenylacetic acid in the circulating organic phase had great influence on the reaction rate, the stability and performance of catalyst and the yield of phenylacetic acid.

Key words: synthesis, phenylacetic acid, carbonylation, phenyl chloride, dichloro-bistriphenylphosphine

Zumin Qiu;Yunbing He;Dianmo Zheng;Fufang Liu. Study on the Synthesis of Phenylacetic Acid by Carbonylation of Benzyl Chloride under Normal Pressure[J]. 能源化学(英文), 2005, 14 (1): 40-46.

Zumin Qiu;Yunbing He;Dianmo Zheng;Fufang Liu. Study on the Synthesis of Phenylacetic Acid by Carbonylation of Benzyl Chloride under Normal Pressure[J]. Journal of Energy Chemistry, 2005, 14 (1): 40-46.

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